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dc.creatorŽivković, Ivana
dc.creatorSavikin, Katarina
dc.creatorŽivković, Jelena
dc.creatorZdunić, Gordana
dc.creatorJanković, Teodora
dc.creatorLazić, Dejan
dc.creatorRadin, Dragoslava
dc.date.accessioned2021-06-07T12:13:53Z
dc.date.available2021-06-07T12:13:53Z
dc.date.issued2021
dc.identifier.issn0921-9668
dc.identifier.urihttp://RIVeC.institut-palanka.rs/handle/123456789/11
dc.description.abstractHuman noroviruses (HuNoV) are the dominant cause of viral gastroenteritis in all age groups worldwide. In this study, we investigated the effects of pomegranate peel extract (PPE) on the reduction of HuNoV in different food models, on surfaces of fresh produce (green onion and cherry tomato), in low-fat milk, and simulated gastrointestinal fluids. The antiviral efficacy of PPE against HuNoV was evaluated by quantifying the number of residual virus genomes using a quantitative reverse transcription PCR (qRT-PCR) assay. Pomegranate peel, considered as a waste product of industrial processing, is known for beneficial health effects and broad antimicrobial activity due to the high content of phenolic compounds and tannins. PPE showed significant antiviral properties against HuNoV both in phosphate-buffered saline (PBS) and simulated gastric fluid. The reduction of HuNoV by pomegranate juice was lower than with PPE, which could be attributed to the lower content of antimicrobial compounds. A pretreatment of cherry tomato and green onion surfaces with PPE significantly reduced the amount of HuNoV particles that adhered to those surfaces during subsequent virus suspension treatment. A detrimental effect of PPE on HuNoV structure was confirmed by transmission electron microscopy. Our results indicate that PPE is a natural antiviral agent effective against food-borne noroviruses.en
dc.publisherSpringer, Dordrecht
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200003/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePlant Foods for Human Nutrition
dc.subjectHuman norovirusen
dc.subjectPomegranate peel extracten
dc.subjectAntiviral effecten
dc.subjectFood modelen
dc.titleAntiviral Effects of Pomegranate Peel Extracts on Human Norovirus in Food Models and Simulated Gastrointestinal Fluidsen
dc.typearticle
dc.rights.licenseBY
dc.citation.other(): -
dc.citation.rankM21~
dc.identifier.doi10.1007/s11130-021-00895-7
dc.identifier.fulltexthttp://RIVeC.institut-palanka.rs/bitstream/id/165/8.pdf
dc.identifier.rcubconv_225
dc.identifier.scopus2-s2.0-85103623738
dc.identifier.wos000637457100002
dc.identifier.pmid33825092
dc.type.versionpublishedVersion


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