TY  - JOUR
AU  - Stikić, Radmila
AU  - Milincić, Danijel D.
AU  - Kostić, Aleksandar
AU  - Jovanović, Zorica
AU  - Gašić, Uroš M.
AU  - Tešić, Živoslav
AU  - Đorđević, Nataša Z.
AU  - Savić, Slađana
AU  - Czekus, Borisz G.
AU  - Pešić, Mirjana
PY  - 2020
UR  - http://RIVeC.institut-palanka.rs/handle/123456789/265
AB  - BACKGROUND:  and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.
PB  - Wiley, Hoboken
T2  - Cereal Chemistry
T1  - Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars
EP  - 633
IS  - 3
SP  - 626
VL  - 97
DO  - 10.1002/cche.10278
ER  - 

@article{
author = "Stikić, Radmila and Milincić, Danijel D. and Kostić, Aleksandar and Jovanović, Zorica and Gašić, Uroš M. and Tešić, Živoslav and Đorđević, Nataša Z. and Savić, Slađana and Czekus, Borisz G. and Pešić, Mirjana",
year = "2020",
abstract = "BACKGROUND:  and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.",
publisher = "Wiley, Hoboken",
journal = "Cereal Chemistry",
title = "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars",
pages = "633-626",
number = "3",
volume = "97",
doi = "10.1002/cche.10278"
}

Stikić, R., Milincić, D. D., Kostić, A., Jovanović, Z., Gašić, U. M., Tešić, Ž., Đorđević, N. Z., Savić, S., Czekus, B. G.,& Pešić, M.. (2020). Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry
Wiley, Hoboken., 97(3), 626-633.
https://doi.org/10.1002/cche.10278

Stikić R, Milincić DD, Kostić A, Jovanović Z, Gašić UM, Tešić Ž, Đorđević NZ, Savić S, Czekus BG, Pešić M. Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry. 2020;97(3):626-633.
doi:10.1002/cche.10278 .

Stikić, Radmila, Milincić, Danijel D., Kostić, Aleksandar, Jovanović, Zorica, Gašić, Uroš M., Tešić, Živoslav, Đorđević, Nataša Z., Savić, Slađana, Czekus, Borisz G., Pešić, Mirjana, "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars" in Cereal Chemistry, 97, no. 3 (2020):626-633,
https://doi.org/10.1002/cche.10278 . .

TY  - JOUR
AU  - Žilić, Slađana
AU  - Dodig, Dejan
AU  - Vančetović, Jelena
AU  - Basić, Zorica
AU  - Titan, Primož
AU  - Đurić, Nenad
AU  - Tolimir, Natasa
PY  - 2017
UR  - http://RIVeC.institut-palanka.rs/handle/123456789/242
AB  - Cereals-based food is one of the major source of Maillard reaction products in the diet. Free amino acids and reducing sugars are considered to be the main precursors in the formation of these heat-induced compounds. In order to determine genetic resources with reduced potential for acrylamide formation, the content of sugars as well as free asparagine were analysed in a total of 30 cultivars of 10 varieties belonging to eight species (Triticum aestivum var. lutescens, T. aestivum var. alba, T. aestivum var. compactum, T. durum, T. spelta, T. dicoccum, Secale cereale, Hordeum vulgare var. nudum, Avena sativa var. nudum, and Zea mays var. indentata) grown at the same location in the 2015 growing season. Our results provide evidence of differences in the content of sugars and asparagine between and within species of small grain cereals and maize. The highest content of glucose, fructose and asparagine was found in cultivars of rye and hull-less oat. All maize varieties examined contained significantly higher amounts of non-reducing and total sugars (on average 1.25% and 2.36%, respectively) than small cereal grain species. Principal component analysis showed a high positive correlation between monoreducing sugars and asparagine in bread wheat, durum wheat and hull-less barley.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
T1  - Free asparagine and sugars profile of cereal species: the potential of cereals for acrylamide formation in foods
EP  - 713
IS  - 5
SP  - 705
VL  - 34
DO  - 10.1080/19440049.2017.1290281
ER  - 

@article{
author = "Žilić, Slađana and Dodig, Dejan and Vančetović, Jelena and Basić, Zorica and Titan, Primož and Đurić, Nenad and Tolimir, Natasa",
year = "2017",
abstract = "Cereals-based food is one of the major source of Maillard reaction products in the diet. Free amino acids and reducing sugars are considered to be the main precursors in the formation of these heat-induced compounds. In order to determine genetic resources with reduced potential for acrylamide formation, the content of sugars as well as free asparagine were analysed in a total of 30 cultivars of 10 varieties belonging to eight species (Triticum aestivum var. lutescens, T. aestivum var. alba, T. aestivum var. compactum, T. durum, T. spelta, T. dicoccum, Secale cereale, Hordeum vulgare var. nudum, Avena sativa var. nudum, and Zea mays var. indentata) grown at the same location in the 2015 growing season. Our results provide evidence of differences in the content of sugars and asparagine between and within species of small grain cereals and maize. The highest content of glucose, fructose and asparagine was found in cultivars of rye and hull-less oat. All maize varieties examined contained significantly higher amounts of non-reducing and total sugars (on average 1.25% and 2.36%, respectively) than small cereal grain species. Principal component analysis showed a high positive correlation between monoreducing sugars and asparagine in bread wheat, durum wheat and hull-less barley.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment",
title = "Free asparagine and sugars profile of cereal species: the potential of cereals for acrylamide formation in foods",
pages = "713-705",
number = "5",
volume = "34",
doi = "10.1080/19440049.2017.1290281"
}

Žilić, S., Dodig, D., Vančetović, J., Basić, Z., Titan, P., Đurić, N.,& Tolimir, N.. (2017). Free asparagine and sugars profile of cereal species: the potential of cereals for acrylamide formation in foods. in Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
Taylor & Francis Ltd, Abingdon., 34(5), 705-713.
https://doi.org/10.1080/19440049.2017.1290281

Žilić S, Dodig D, Vančetović J, Basić Z, Titan P, Đurić N, Tolimir N. Free asparagine and sugars profile of cereal species: the potential of cereals for acrylamide formation in foods. in Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment. 2017;34(5):705-713.
doi:10.1080/19440049.2017.1290281 .

Žilić, Slađana, Dodig, Dejan, Vančetović, Jelena, Basić, Zorica, Titan, Primož, Đurić, Nenad, Tolimir, Natasa, "Free asparagine and sugars profile of cereal species: the potential of cereals for acrylamide formation in foods" in Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, 34, no. 5 (2017):705-713,
https://doi.org/10.1080/19440049.2017.1290281 . .

TY  - JOUR
AU  - Krstonijević-Živanović, Nina
AU  - Prodanović, Slaven
AU  - Girek, Zdenka
PY  - 2015
UR  - http://RIVeC.institut-palanka.rs/handle/123456789/165
AB  - The present study was conducted in order to analyze the divergence of the fourteen native populations of St. John’s wort (Hypericum perforatum L.) originating from different locations of Serbia based on six leaf morphological characteristics including leaf length and width, leaf area, leaf length/width ratio and light and dark gland density on leaves. Plants were grown under the same ex situ conditions, along with the standard cultivar ‘Maya’, used as control. The one way analysis of variance (ANOVA) revealed highly significant differences (p lt 0.01) among investigated populations of H. perforatum in all studied characteristics. The highest morphological heterogeneity within populations was observed in the leaf light gland density (CV = 9.71 - 47.81%) and was followed by leaf dark gland density (CV = 12.94 - 42.19%). These characteristics are considered as important morphological markers, indicating thereby the relative extent of biologically active substances present in the analyzed genotypes of this species, without the need of chemical estimation. The noted morphological variation in H. perforatum probably had a genetic character as all plants had grown under uniform conditions. One can therefore expect that wild populations of H. perforatum are potentially important sources of genetic variation that could be utilized in breeding programs for an improvement of cultivated material and/or selection of new cultivars. Based on the results of UPGMA cluster analysis a group of genotypes of H. perforatum are distinguished from others by higher leaf gland density and presumably higher contents of the biologically active substances if compared with the cv.’Maya’ and hence could be considered in the future breeding programs.
AB  - U radu je analizirana divergentnost četrnaest autohtonih populacija kantariona (Hypericum perforatum L.) poreklom sa različitih lokaliteta u Srbiji u odnosu na šest morfoloških osobina lista: dužinu i širinu lista, odnos dužine i širine lista, lisnu površinu i gustinu providnih i tamnih žlezda na listovima. Genotipovi su gajeni u istimex situ uslovima zajedno sa standardnom sortom Maja, korišćenom kao kontrola. Rezultati ANOVA testa identifikovali su statistički znacajne (p lt 0,01) razlike između analiziranih populacija po svim ispitivanim osobinama. Najvarijabilnije osobine unutar populacija bile su gustina providnih žlezda (CV = 58,75%) i gustina tamnih žlezda na listu (CV = 51,00%), koje se smatraju značajnim morfološkim markerima za sadržaj bioaktivnih supstanci kod kantariona.Uočena morfološka varijabilnost verovatno ima geneticku osnovu, s obzirom da su analizirani genotipovi gajeni pod uniformnim sredinskim uslovima.Stoga se može ocekivati da divlje populacije kantariona predstavljaju potencijalno značajan izvor genetičke varijabilnosti, koji bi se mogao koristiti u programima oplemenjivanja u cilju poboljšanja postojećih i/ili selekciju novih sorti.Klaster analiza po metodi UPGMA je izdvojila grupu genotipova koji se od drugih razlikuju prema većoj gustini lisnih žlezda u poređenju sa standardnom sortom Maja, i koji bi stoga mogli da predstavljaju značajan početni materijal u budućim programima oplemenjivanja.
PB  - Institut PKB Agroekonomik, Padinska skela
T2  - Zbornik naučnih radova Instituta PKB Agroekonomik
T1  - Divergence of the local populations of St. John’s wort (Hypericum perforatum L.) based on leaf morphological traits
T1  - Divergentnost domaćih populacija kantariona (Hypericum perforatum L.) po morfoloskim osobinama lista
EP  - 149
IS  - 1-2
SP  - 141
VL  - 21
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_3980
ER  - 

@article{
author = "Krstonijević-Živanović, Nina and Prodanović, Slaven and Girek, Zdenka",
year = "2015",
abstract = "The present study was conducted in order to analyze the divergence of the fourteen native populations of St. John’s wort (Hypericum perforatum L.) originating from different locations of Serbia based on six leaf morphological characteristics including leaf length and width, leaf area, leaf length/width ratio and light and dark gland density on leaves. Plants were grown under the same ex situ conditions, along with the standard cultivar ‘Maya’, used as control. The one way analysis of variance (ANOVA) revealed highly significant differences (p lt 0.01) among investigated populations of H. perforatum in all studied characteristics. The highest morphological heterogeneity within populations was observed in the leaf light gland density (CV = 9.71 - 47.81%) and was followed by leaf dark gland density (CV = 12.94 - 42.19%). These characteristics are considered as important morphological markers, indicating thereby the relative extent of biologically active substances present in the analyzed genotypes of this species, without the need of chemical estimation. The noted morphological variation in H. perforatum probably had a genetic character as all plants had grown under uniform conditions. One can therefore expect that wild populations of H. perforatum are potentially important sources of genetic variation that could be utilized in breeding programs for an improvement of cultivated material and/or selection of new cultivars. Based on the results of UPGMA cluster analysis a group of genotypes of H. perforatum are distinguished from others by higher leaf gland density and presumably higher contents of the biologically active substances if compared with the cv.’Maya’ and hence could be considered in the future breeding programs., U radu je analizirana divergentnost četrnaest autohtonih populacija kantariona (Hypericum perforatum L.) poreklom sa različitih lokaliteta u Srbiji u odnosu na šest morfoloških osobina lista: dužinu i širinu lista, odnos dužine i širine lista, lisnu površinu i gustinu providnih i tamnih žlezda na listovima. Genotipovi su gajeni u istimex situ uslovima zajedno sa standardnom sortom Maja, korišćenom kao kontrola. Rezultati ANOVA testa identifikovali su statistički znacajne (p lt 0,01) razlike između analiziranih populacija po svim ispitivanim osobinama. Najvarijabilnije osobine unutar populacija bile su gustina providnih žlezda (CV = 58,75%) i gustina tamnih žlezda na listu (CV = 51,00%), koje se smatraju značajnim morfološkim markerima za sadržaj bioaktivnih supstanci kod kantariona.Uočena morfološka varijabilnost verovatno ima geneticku osnovu, s obzirom da su analizirani genotipovi gajeni pod uniformnim sredinskim uslovima.Stoga se može ocekivati da divlje populacije kantariona predstavljaju potencijalno značajan izvor genetičke varijabilnosti, koji bi se mogao koristiti u programima oplemenjivanja u cilju poboljšanja postojećih i/ili selekciju novih sorti.Klaster analiza po metodi UPGMA je izdvojila grupu genotipova koji se od drugih razlikuju prema većoj gustini lisnih žlezda u poređenju sa standardnom sortom Maja, i koji bi stoga mogli da predstavljaju značajan početni materijal u budućim programima oplemenjivanja.",
publisher = "Institut PKB Agroekonomik, Padinska skela",
journal = "Zbornik naučnih radova Instituta PKB Agroekonomik",
title = "Divergence of the local populations of St. John’s wort (Hypericum perforatum L.) based on leaf morphological traits, Divergentnost domaćih populacija kantariona (Hypericum perforatum L.) po morfoloskim osobinama lista",
pages = "149-141",
number = "1-2",
volume = "21",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_3980"
}

Krstonijević-Živanović, N., Prodanović, S.,& Girek, Z.. (2015). Divergence of the local populations of St. John’s wort (Hypericum perforatum L.) based on leaf morphological traits. in Zbornik naučnih radova Instituta PKB Agroekonomik
Institut PKB Agroekonomik, Padinska skela., 21(1-2), 141-149.
https://hdl.handle.net/21.15107/rcub_agrospace_3980

Krstonijević-Živanović N, Prodanović S, Girek Z. Divergence of the local populations of St. John’s wort (Hypericum perforatum L.) based on leaf morphological traits. in Zbornik naučnih radova Instituta PKB Agroekonomik. 2015;21(1-2):141-149.
https://hdl.handle.net/21.15107/rcub_agrospace_3980 .

Krstonijević-Živanović, Nina, Prodanović, Slaven, Girek, Zdenka, "Divergence of the local populations of St. John’s wort (Hypericum perforatum L.) based on leaf morphological traits" in Zbornik naučnih radova Instituta PKB Agroekonomik, 21, no. 1-2 (2015):141-149,
https://hdl.handle.net/21.15107/rcub_agrospace_3980 .